The most intensive clinical studies of psychedelic psychotherapy were done in the United States and Europe from the early 1950s through the early 1970s. During that time, more than 40,000 human subjects, both mentally healthy volunteers and psychiatric patients, received LSD, psilocybin and mescaline in scientific research. More than 1,000 clinical studies, medical reports and literature reviews have been published in peer-reviewed scientific journals demonstrating that psychedelic psychotherapy is effective as an alternative approach to the treatment of various addictions. The same studies also demonstrate that this technique is highly effective in the treatment of patients with neurotic disorders, depression, psychosomatic illnesses, and personality disorders, as well as death anxiety in individuals dying from cancer or other incurable diseases.

The psychiatrist, Stanislav Grof, M.D., developed the most comprehensive theory of psychedelic psychotherapy. He believed that a therapeutic experience of a symbolic death and rebirth of ego allowed clients to work through their deep traumatic fixations in the psyche, or unconscious mind. Dr. Grof designed a specific psychotherapeutic approach and applied LSD psychedelic psychotherapy successfully with more than 750 patients. He discouraged his clients from analyzing their psychological problems or clinical symptoms. Instead, he assisted patients in transcending their inflexible maladjustive patterns. Dr. Grof placed a strong emphasis on the growth potential of his clients and devised a way to enhance this process. He summarized his psychotherapeutic approach in the comprehensive textbook entitled LSD Psychotherapy.

Evgeny Krupitsky, M.D., a Russian psychiatrist, began using ketamine psychedelic psychotherapy (KPP) in 1985, for treatment of various drug dependencies, such as alcohol, heroin and ephedrine. Dr. Krupitsky has done the most comprehensive clinical research on this subject of ketamine psychedelic psychotherapy and has treated more than 1,000 patients in his center without complications. In 1997, Dr. Krupitsky published an extensive review of the results of his KPP research in the Journal of Psychoactive Drugs. He concluded that KPP is a safe and effective alternative treatment of addiction. In addition, Dr. Krupitsky reported that KPP is also an effective tool for treatment of post-traumatic stress disorder, reactive depression, neurotic disorders and avoidant personality disorders. He reported that his patients showed significant improvement after KPP. They became less anxious and depressed, more responsible and emotionally mature, with increased ego strength and positive changes in life values, self-concept and spiritual development.

The Kolp Institute’s WELL Program adapts the approach of both researchers to help clients achieve physical and psychological well-being and accelerate their psycho-spiritual growth.